Report of the 31st Ucla International Kir Exchange

For the 31st KIR Exchange, 4 DNA samples (KDNA#121-124) were shipped to participating laboratories on May 8, 2013. A total of 68 laboratories submitted their KIR typing results. The majority of the laboratories used either commercial or in-house developed sequence-specific primer (SSP) based PCR and sequence-specific oligonucleotide probe (SSOP) typing systems. The results for the 31st KIR Exchange are summarized in Table 1 and individual laboratory results reported for each DNA sample are provided in Tables 2-5. Subtyping results for KIR2DL3, 2DL5, 3DL1, 2DS1, 2DS3, 2DS4, and 3DP1 loci were reported by some laboratories. The subtypes for 2DS4 and 3DP1 are denoted as FULL or DEL. The positive/negative assignments for all 4 DNA samples were reported without any discrepancy for 8 of the 16 tested KIR loci (KIR2DL2, 2DL4, 2DL5, 3DL1, 3DL2, 3DL3, 2DS2, and 2DS3). Discrepant results from the consensus typing are italicized in tables 1-5, and described in the summation for each sample. Discrepancies at the allele level are not italicized. Participants are encouraged to resolve the discrepancies so that the information can be shared to develop reliable KIR typing systems. We thank you for your continued participation in the UCLA KIR Exchange program.